Comparative Merits of Sodium and Procaine Penicillin

Treatment of gonorrhoea with cotrimoxazole, procaine penicillin alone, and procaine penicillin plus probenecid.

Successful treatment of gonorrhoea with cotri-moxazole* has now been reported by several workers who gave one tablet four times a day for 5 days, observed a failure rate of 38 per cent. of the 86 men followed. They claimed that in 45 per cent. of the failures a carrier state resulted which was detected by routine examination of Gram-stained smears in all cases after treatment; cultures were not...

Toxic epidermal necrolysis due to procaine penicillin.

I toxic epidermal necrolysis (TEN), a wide layer of skin is peeled and an immature skin layer appears. In a short period, an epidermal necrolysis characterized by scalded appearance of skin due to febrile toxic reaction develops. The mortality rate of this disease is high (20-70%), due to dramatic drug reactions of the skin. The disease resembles mostly to erythema multiforme (EM), Steven Johns...

High dosage procaine penicillin combined with ampicillin in the treatment of gonorrhoea after failure with standard procaine penicillin dosage.

This is a preliminary report suggesting a method of management of cases of gonorrhoea in which there has been failure of treatment with standard doses of penicillin. Over the past 10 years there has been a steady increase in the number of strains of gonococci isolated which show an increased resistance to the action of penicillin (Curtis and Wilkinson, 1958). The Medical Research Council (1961)...

PAM plus probenecid and procaine penicillin plus probenecid in gonorrhoea.

In 1944, when gonorrhoea responded to 100,000 units of crystalline penicillin given in divided doses, Miller, Scott, and Moeller (1944) observed that the gonococcus was cleared from the urethral secretions within 1 to 6 hours. 23 years later, Holmes, Johnson, and Floyd (1967), in the Far East, noted that only one case, a therapeutic failure, out of twenty treated with 2-4 m.u. procaine penicill...

Treatment of gonorrhoea with procaine penicillin plus probenecid.